PSVIII-26 Gene editing of complex traits
نویسندگان
چکیده
منابع مشابه
The Complex Inheritance of Maize Domestication Traits and Gene Expression
The genetic basis for morphological change in divergent species is a central question in evolutionary biology. The domestication of maize from its wild progenitor, teosinte, is an excellent system to address this question. We explore the large effect on domestication phenotypes of a poorly understood region of the maize genome using a chromosome five specific mapping population. Unlike other la...
متن کاملGene-Gene and Gene-Environment Interactions Underlying Complex Traits and their Detection.
Among these methods emerged recently, data reduction approaches (a constructive induction strategy) such as the multifactor dimensionality reduction method (MDR) [36,37], the combinatorial partitioning method [38], and the restricted partition method [39], are promising to address the multidimensionality problems. Rather than modeling the interaction term per se as with regression methods, a da...
متن کاملGMDR: Versatile Software for Detecting Gene-Gene and Gene-Environ- ment Interactions Underlying Complex Traits
Identification of multifactor gene-gene (G×G) and gene-environment (G×E) interactions underlying complex traits poses one of the great challenges to today's genetic study. Development of the generalized multifactor dimensionality reduction (GMDR) method provides a practicable solution to problems in detection of interactions. To exploit the opportunities brought by the availability of diverse d...
متن کاملMultivariate Dimensionality Reduction Approaches to Identify Gene-Gene and Gene-Environment Interactions Underlying Multiple Complex Traits
The elusive but ubiquitous multifactor interactions represent a stumbling block that urgently needs to be removed in searching for determinants involved in human complex diseases. The dimensionality reduction approaches are a promising tool for this task. Many complex diseases exhibit composite syndromes required to be measured in a cluster of clinical traits with varying correlations and/or ar...
متن کاملGene Editing Versus Morphants
Kok et al. conclude that results with Morpholino oligos, which are not recapitulated by natural mutations or gene editing mutations, must be due to off-target effects and, when morphants and mutants differ, they contend that antisense oligo studies should be disregarded. Morpholinos and gene editing mutagenesis are very different technologies and, even if both work perfectly, may yield differen...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Animal Science
سال: 2019
ISSN: 0021-8812,1525-3163
DOI: 10.1093/jas/skz258.529